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Autoimmune polyendocrine syndrome : ウィキペディア英語版
Autoimmune polyendocrine syndrome

In medicine, autoimmune polyendocrine syndromes, also called polyglandular autoimmune syndrome (PGAS), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected.
There are three "autoimmune polyendocrine syndromes", and a number of other diseases which have endocrine autoimmunity as one of their features.
== The syndromes ==

* Autoimmune polyendocrine syndrome type 1 (APECED or Whitaker's syndrome)
* Autoimmune polyendocrine syndrome type 2
* The most serious but rarest form is the ''X-linked polyendocrinopathy, immunodeficiency and diarrhea''-syndrome, also called XLAAD (X-linked autoimmunity and allergic dysregulation) or IPEX (immune dysfunction, polyendocrinopathy, and enteropathy, X-linked). This is due to mutation of the ''FOXP3'' gene on the X chromosome. Most patients develop diabetes and diarrhea as neonates and many die due to autoimmune activity against many organs. Boys are affected, while girls are carriers and might suffer mild disease.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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